院长助理:聂瑾芳 教授

 

 

聂瑾芳,汉族,1983年出生于湖南。博士/博士后,教授,硕士研究生导师

 

研究领域:化学生物传感、化学计量学。E-mailgod78@163.comNiejinfang@glut.edu.cn

 

(一)教育与工作经历

2011.03-至今:桂林理工大学,化学与生物工程学院,副教授(2012)、教授(2017);

2016.03-2016.09:广西科学技术厅(挂职),基础研究处副处长;

2014.11-2015.11:英国牛津大学(University of Oxford),化学系,博士后(合作导师:Tom Brown 教授);

2005.09-2010.12:湖南大学,化学生物传感与计量学国家重点实验室,分析化学专业,获理学博士学位(导师:吴海龙教授、俞汝勤院士);

2001.09-2005.07:湖南大学,化学化工学院,应用化学专业,获理学学士学位(导师:吴海龙教授)。

 

(二)教学工作

本科生课程:《分析化学》、《计算机在分析化学中的应用》、《环境分析化学》、《精细化学品化学》、《食品化学与分析》;研究生课程:《分子科学计算基础》、《环境污染化学》。主持建设的《分析化学》中英文双语在线开放课程于20185月在“学堂在线”主站平台上线。目前,来自中国、美国、英国、意大利等世界各国的在线选课人数超过1.74万(截至20195月)。

代表性教学/教改获奖:

ž   2018年度教育部在线研究中心“智慧教学之星”

ž   桂林理工大学第十四届十佳青年授课教师

ž   桂林理工大学2013年度优秀青年授课老师

ž   第十一届全国多媒体课件大赛优秀奖

ž   第十二届全国多媒体课件大赛优秀奖

ž   第十二届广西区教育教学软件大赛二等奖

ž   第八届广西高校教学软件大赛优秀奖

ž   桂林理工大学2013年首届微课教学比赛二等奖

ž   桂林理工大学第二届多媒体教学软件比赛二等奖

ž   桂林理工大学第三届多媒体教学软件比赛二等奖

ž   桂林理工大学“欣羽创新人才发展奖”

ž   桂林理工大学2014年度优秀班导师

指导本科生/研究生获奖:

ž   12届全国电分析化学学术会议论文墙展二等奖

ž   2014年度广西区优秀硕士毕业生

ž   2015年度广西高校化学化工类论文及设计竞赛一等奖

ž   桂林市第二届优利特杯大学生科技创新设计大赛一等奖

ž   桂林理工大学2014年度优秀硕士毕业生

ž   桂林理工大学2017年度优秀硕士学位论文

 

(三)科研工作

主持国家自然科学基金项目3项、广西重点研发计划项目1项、广西自然科学基金项目1项、广西高等学校科研项目1项、桂林理工大学博士科研启动基金项目1项。在Analytical ChemistryChemical CommunicationsBiosensors and BioelectronicsChemometrics and Intelligent Laboratory SystemsJournal of Chemometrics等分析化学领域国际主流期刊发表SCI收录论文50余篇,其中影响因子大于4期刊论文26篇、封底论文3篇。论文他引1200篇次(单篇最高被引123次),个人H因子为20。研究成果被科技媒体X-MOL专题报道2次。作为主要成员参与译著《化学计量学实用指南》。获授权中国发明专利3项。

主持的科研项目:

ž   基于灵敏调控纸润湿性机制的重金属免仪器快速定量检测新方法研究,国家自然科学基金项目,项目批准号21765007,执行年限2018-2021

ž    “基于杂交链式反应和三阶校正的转录因子高灵敏荧光检测新方法研究,国家自然科学基金项目,项目批准号21565012,执行年限2016-2019

ž   基于图案化纸和超疏水效应抑制背景信号的核酸适配体生物分析新方法研究,国家自然科学基金项目,项目批准号21205021,执行年限2013-2015

ž   水环境重金属免仪器快速定量检测技术开发及应用,广西重点研发计划项目,项目编号桂科AB17129003,执行年限2017-2020

ž    “多组分荧光免疫分析结合化学计量学方法用于生物体液中多项肿瘤标记物的无干扰同时定量检测,广西自然科学基金项目,项目批准号2012GXNSFBA053029,执行年限2012-2014

ž   基于二阶校正的三维荧光分析用于药物与DNA的相互研究,广西高等学校科研项目,项目批准号201203YB090,执行年限2012-2014

ž   复杂体系中多维数据解析的化学计量学方法研究,桂林理工大学博士科研启动基金项目,项目批准号002401003337,执行年限2011-2014

 

(四)主要学术与社会兼职

教育部学位与研究生教育发展中心学位论文评审专家;广西发展战略研究会专家;广西科技计划项目评审专家;2018年广西职业院校信息化教学大赛评委;Journal of Chromatogrphy BApplied Surface ScienceElectrophoresis等国际SCI期刊审稿专家。

 

(五)代表性学术论文(*通讯作者)

1.         Wencheng Xiao, Yiming Gao, Yun Zhang,* Jiao Li, Zhaoying Liu, Jinfang Nie,* Jianping Li. Enhanced 3D paper-based devices with a personal glucose meter for highly sensitive and portable biosensing of silver ion. Biosensors and Bioelectronics, 2019, 137, 154-160.

2.         Haiyan Fu,* Qiaobo Yin, Huili Wang, Jinfang Nie, Wencheng Xiao, Zhaoying Liu, Yijing Chen, Yun Zhang.* Target-triggered in situ autocatalysis in nanopore membrane for point-of-care testing of sub-nanomolar Ag+. Sensors and Actuators: B. Chemical, 2019, 287, 290-295.

3.         Jiao Li, Jie Xu, Wenying Jin, Zhongsheng Yi,* Chenbo Cai, Xuefen Huang, Jinfang Nie* and Yun Zhang. Fluorescent kinetics combined with fourth-order calibration for the determination of diclofenac sodium in environmental water. Analytical and Bioanalytical Chemistry, 2019, 411(10), 2019-2029.

4.         Lang Zhang†, Yali Yuan†, Yun Zhang,* Zhaoying Liu, Wencheng Xiao, Jinfang Nie*, and Jianping Li. Equipment-Free Quantitative Aptamer-Based Colorimetric Assay Based on Target-Mediated Viscosity Change. ACS Omega, 2018, 3(2), 1451-1457.

5.         王兵月, 乐惠泽, 聂瑾芳,* 肖文成, 刘召应, 张云.* 基于目标介导纳米金凝集的Ag+目视检测方法. 化学传感器, 2018, 1, 48-54. 封面论文.

6.         H. L. Wang, Y. Zhang,* R. X. Li, J. F. Nie,* A. H. El-Sagheer, T. Brown, Z. Y. Liu and W. C. Xiao. Instrument-free quantitative gold nanoparticle-based liquid-phase colorimetric assays for use in resource-poor environments. Chemical Communications, 2017, 53, 8407-8410. 封底论文.

7.         J. H. Yang, Y. Zhang,* L. Zhang, H. L. Wang, J. F. Nie,* Z. X. Qin, J. Li and W. C. Xiao. Analyte-triggered autocatalytic amplification combined with gold nanoparticle probes for colorimetric detection of heavy-metal ions. Chemical Communications, 2017, 53, 7477-7480.

8.         H.Y. Fu,* J.H. Yang, L. Guo, J.F. Nie,* Q.B. Yin, L. Zhang, Y. Zhang.* Using the Rubik's Cube to directly produce paper analytical devices for quantitative point-of-care aptamer-based assays. Biosensors and Bioelectronics, 2017, 96, 194-200.

9.         S.W. Le, H. Zhou, J.F. Nie,* C.H. Cao, J.N. Yang,* H.C. Pan, J.P. Li and Y. Zhang.* Fabrication of paper devices via laser-heating-wax-printing for high-tech enzyme-linked immunosorbent assays with low-tech pen-type pH meter readout. Analyst, 2017, 142, 511-516.

10.     L. Zhang, J.F. Nie,* H.L. Wang, J.H. Yang, B.Y. Wang, Y. Zhang* and J.P. Li. Instrument-free quantitative detection of alkaline phosphatase using paper-based devices. Analytical Methods, 2017, 9, 3375-3379

11.     Nie J. F., Brown T., Zhang Y.* New two dimensional liquid-phase colorimetric assay based on old iodine–starch complexation for the naked-eye quantitative detection of analytes. Chemical Communications, 2016, 52: 7454-7457. 封底论文; X-MOL专题报道.

12.     Zhang Y.,* Yang J. N., Nie J. F.,* Yang J. H., Gao D., Zhang L., Li J. P. Enhanced ELISA using a handheld pH meter and enzyme-coated microparticles for the portable, sensitive detection of proteins. Chemical Communications, 2016, 52: 3474-3477. 封底论文; X-MOL专题报道.

13.     Zhang Y.,* Gao D., Fan J. L., Nie J. F.,* Le S. W., Zhu W. Y., Yang J. N., Li J. P. Naked-eye quantitative aptamer-based assay on paper device. Biosensors and Bioelectronics, 2016, 78: 538-546.

14.     Nie J. F.,* Li B., Zhang Y.,* Fan J. L., Yi Z. S., Cai Z. R. High-order calibration for the spectrofluorimetric determination of pesticides based on photochemical derivatization. A solution of the problems of inner-filter effects and matrix interferences in complex environmental water. Chemometrics and Intelligent Laboratory Systems, 2016, 156: 36-53.

15.     Zhang Y.,* Fan J. L., Nie J. F.,* Le S. W., Zhu W. Y., Gao D., Yang J. N., Zhang S. B., Li J. P. Timing readout in paper device for quantitative point-of-use hemin/G-quadruplex DNAzyme-based bioassays. Biosensors and Bioelectronics, 2015, 73: 13-18.

16.     Zhang Y.,* Zhou C. B., Nie J. F.,* Le S. W., Qin Q., Liu F., Li Y. P. Equipment-free quantitative measurement for microfluidic paper-based analytical devices fabricated using the principles of movable-type printing. Analytical Chemistry, 2014, 86(4): 2005-2012.

17.     Zhang Y.,* Liu F., Nie J. F.,* Jiang F. Y., Zhou C. B., Yang J. N., Fan J. L., Li J. P. An electrochemical sensing platform based on local repression of electrolyte diffusion for single-step, reagentless, sensitive detection of a sequencespecific DNA-binding protein. Analyst, 2014, 139(9): 2193-2198.

18.     Nie J. F., Liang Y. Z., Zhang Y.,* Le S. W., Li D. N., Zhang S. B. One-step patterning of hollow microstructures in paper by laser cutting to create microfluidic analytical devices. Analyst, 2013, 138(2): 671-676.

19.     Nie J. F., Zhang Y.,* Lin L. W., Zhou C. B., Li S. H., Zhang L. M., Li J. P. Low-cost fabrication of paper-based microfluidic devices by one-step plotting. Analytical Chemistry, 2012, 84(15): 6331-6335.

20.     Nie J. F., Zhang Y.,* Wang H., Wang S. P., Shen G. L. Superhydrophobic surface-based magnetic electrochemical immunoassay for detection of Schistosoma japonicum antibodies. Biosensors and Bioelectronics, 2012, 33(1): 23-28.

21.     Nie J. F., Zhang Y.,* Yi Z. S., Zou H. Y., Fu H. Y., Wu H. L. Advanced chemometric algorithm coupled to subspace projection technique between original and pseudo samples: A snapshot of chemical rank estimation for high-order data. Chemometrics and Intelligent Laboratory Systems, 2012, 118: 211-218.

22.     Shao S. Z., Wu H. L.,* Li S. F., Nie J. F., Wang K. Y., Liang Y., Yu R. Y. Determination of levodopa in both human Urine and plasma samples using excitation–emission matrix fluorescence coupled with second-order calibration. Journal of Analytical Science, 2012, 24: 373-378.

23.     Zhang Y., Wang H.,* Li J. P., Nie J. F., Zhang Y. W, Shen G. L.,* Yu. R. Q. Nitrocellulose strip array assembled on superhydrophobic surface: An aqueous solution diffusion-localized platform for multianalyte immunogold staining assays. Biosensors and Bioelectronics, 2011, 26 (7): 3272-3277.

24.     聂瑾芳, 吴海龙*, 张云, 刘亚娟, 王建瑶, 李勇, 俞汝勤. 三线性分解方法用于激发-发射矩阵荧光数据中一阶瑞利散射的扣除. 中国科学: 化学, 2011 , 41(11): 1740-1749.

25.     Fu H. Y., Wu H. L.*, Yu Y. J., Yu L. L., Zhang S. R., Nie J. F., Li S. F., Yu R. Q. A new third-order calibration method with application for analysis of four-way data arrays. Journal of Chemometrics, 2011, 25: 408-429.

26.     Yu Y. J., Wu H. L.*, Nie J. F., Zhang S. R., Li S. F., Li Y. N., Zhu S. H., Yu R. Q. A comparison of several trilinear second-order calibration algorithms. Chemometrics and Intelligent Laboratory Systems, 2011, 106: 93-107.

27.     Liu Y. J., Wu H. L.,* Kang C., Gu H. W., Nie J. F., Li S. S., Su Z. Y., Yu R. Q. Four-way self-weighted alternating normalized residue fitting algorithm with application for the analysis of serotonin in human plasma. Analytical Sciences, 2011, 28(11): 1097-1104.

28.     Nie J. F., Wu H. L.,* Wang J. Y., Liu Y. J., Yu. R. Q. Chemical rank estimation for excitation-emission matrix fluorescence data by region-based moving window subspace projection technique and Monte Carlo simulation. Chemometrics and Intelligent Laboratory Systems, 2010, 104: 271-280.

29.     Nie J. F., Wu H. L.*, Zhang S. R., Yu Y. J., Yu R. Q. Self-weighted alternating normalized residue fitting algorithm with application to quantitative analysis of excitation-emission matrix fluorescence data. Analytical Methods, 2010, 2: 1918-1926.

30.     Li S. F., Wu H. L.*, Yu Y. J., Li Y. N., Nie J. F., Fu H. Y., Yu R. Q. Quantitative analysis of levodopa, carbidopa and methyldopa in human plasma samples using HPLC-DAD combined with second-order calibration based on alternating trilinear decomposition algorithm. Talanta, 2010, 81: 805-812.

31.     Cai C. B., Xu L., Han Q. J., Wu H. L., Nie J. F., Fu H. Y., Yu R. Q.* Combining the least correlation design, wavelet packet transform and correlation coefficient test to reduce the size of calibration set for NIR quantitative analysis in multi-component systems. Talanta, 2010, 81: 799-804.

32.     Zou H. Y., Wu H. L.*, Fu H. Y., Tang L. J., Xu L., Nie J. F., Yu R. Q. Variable-weighted least-squares support vector machine for multivariate spectral analysis. Talanta, 2010, 80: 1698-1701.

33.     Zou H. Y., Wu H. L.,* Li Y. N., Nie J. F., Fu H. Y., Li S. F., Ouyang L. Q., Yu R. Q. Simultaneous determination of dextromethorphan and quinidine in biological fluids by excitation-emission matrix fluorescence coupled with second-order calibration methods. Analytical Letters, 2010, 43, 2739-2750.

34.     Li S. F., Wu H. L.,* Huang L., Li Y. N., Nie J. F., Zhang S. R., Yu R. Q. Quantitative analysis of fluphenazine hydrochloride in human urine samples using excitation-emission matrix fluorescence based on oxidation derivation and combined with second-order calibration methods. Analytical Methods, 2010, 2, 1069-1077.

35.     Fu H. Y., Wu H. L.,* Zou H. Y., Tang L. J., Xu L, Cai C. B., Nie J. F., Yu R. Q. Automatic configuration of optimized sample-weighted least-squares support vector machine by particle swarm optimization for multivariate spectral analysis. Analytical Methods, 2010, 2: 282-288.

36.     Fu H. Y., Wu H. L.,* Nie J. F., Yu Y. J., Zou H.Y., Yu R. Q. Highly sensitive fluorescence quantification of irinotecan in biological fluids with the aid of second-order advantage. Chinese Chemical Letters, 2010, 21(12): 1482-1486.

37.     Zhang Y., Wang H.,* Nie J. F., Zhang Y. W., Shen G. L.,* Yu. R. Q. Individually addressable microelectrode arrays fabricated with gold-coated pencil graphite particles for multiplexed and high sensitive impedance immunoassays. Biosensors and Bioelectronics, 2009, 25(1): 34-40.

38.     Wu H. L.*, Nie J. F., Yu Y. J., Yu. R. Q. Multi-way chemometric methodologies and applications: A central summary of our research work (邀请综述). Analytica Chimica Acta, 2009, 650: 131-142.

39.     Zhang Y., Wang H.,* Nie J. F., Zhou H., Shen G. L.*, Yu R. Q. Mussel-inspired fabrication of encoded polymer films for electrochemical identification. Electrochemistry Communication, 2009, 11: 1936-1939.

40.     OuYang L. Q., Wu H. L.*, Nie J. F., Zhang Y., Zou H. Y., Fu H. Y., Yu R. Q. Simultaneous determination of psoralen and isopsoralen in plasma and Chinese medicine Xian Ling Gu Bao capsule by using HPLC-DAD coupled with alternating trilinear decomposition algorithm. Analytica Chimica Acta, 2009, 650: 160-166.

41.     Zou H. Y., Wu H. L.*, OuYang L. Q., Zhang Y., Nie J. F., Fu H. Y., Yu R. Q. Fluorescent quantification of terazosin hydrochloride content in human plasma and tablets using second-order calibration based on both parallel factor analysis and alternating penalty trilinear decomposition. Analytica Chimica Acta, 2009, 650: 143-149.

42.     Zhu S. H., Wu H. L.*, Xia A. L., Nie J. F., Bian Y. C., Cai C. B., Yu R. Q, Excitation-emission-kinetic fluorescence coupled with third-order calibration for quantifying carbaryl and investigating the hydrolysis in effluent water. Talanta, 2009, 77: 1640-1646.

43.     Wang X. M., Wu H. L.,* Nie J. F., Yu R. Q. Rapid determination of bitertanol content in banana using three-dimensional fluorescence coupled with second-order calibration. Chinese Journal of Analytical Chemistry, 2009, 37: 811-816.

44.     Li Y. N., Wu H. L.,* Nie J. F., Li S. F., Yu Y. J., Zhang S. R., Yu R. Q. Interference-free determination of abscisic acid and gibberellin in plant samples by using excitation-emission matrix fluorescence based on oxidation derivatization coupled with second-order calibration methods. Analytical Methods, 2009, 1: 115-122.

45.     Li Y. N., Wu H. L.,* Zhang S. R., Nie J. F., Yu Y. J., Wang X. M., Yu R. Q. Determination of indole-3-Acetic acid in soil using excitation-emission matrix fluorescence with trilinear decomposition-based calibration methods. Analytical Sciences, 2009, 25: 83-88. 

46.     Zou H. Y., Wu H. L.,* Zhang Y., Li S. F., Nie J. F., Fu H. Y., Yu R. Q. Studying the interaction of pirarubicin with DNA and determining pirarubicin in human urine samples: Combining excitation-emission fluorescence matrices with second-order calibration methods. Journal of Fluorescence, 2009, 6: 955-966.

47.     Li S. F., Wu H. L.,* Xia A L., Zhu S. H., Nie J. F., Yu R. J., Yu R. Q. Quantitative analysis of epinephrine in human plasma samples using kinetic fluorometric method combined with second-order calibration. Analytical Sciences, 2009, 25: 1231-1236.

48.     Nie J. F., Wu H. L.*, Wang X. M., Zhang Y., Zhu S. H., Yu R. Q. Determination of testosterone propionate in cosmetics using excitation-emission matrix fluorescence based on oxidation derivatization with the aid of second-order calibration methods. Analytica Chimica Acta, 2008, 628: 24-32.

49.     Nie J. F., Wu H. L.*, Zhu S. H., Han Q. J., Fu H. Y., Li S. F., Yu R. Q. Simultaneous determination of 6-methylcoumarin and 7-methoxycoumarin in cosmetics using three-dimensional excitation–emission matrix fluorescence coupled with second-order calibration methods. Talanta, 2008, 75: 1260-1269.

50.     Cai C. B., Han Q. J., Tang L. J., Nie J. F., OuYang L. Q., Yu R. Q.* Treating NIR data with orthogonal discrete wavelet transform: Predicting concentrations of a multi-component system through a small-scale calibration set. Talanta, 2008, 77: 822-826.

51.     Wang X. M., Wu H. L.*, Nie J. F., Li Y. N., Yu Y. J., Yu R. Q. Rapid determination of thiabendazole in orange extract using excitation-emission matrix fluorescence and second-order calibration based on alternating trilinear decomposition/alternating normalization-weighted error algorithms. Science in China, Series B: Chemistry, 2008, 51: 729-735.

52.     王雪梅, 吴海龙*, 聂瑾芳, 李元娜, 于永杰, 俞汝勤. 激发发射荧光二阶张量校正算法快速检测桔子中噻苯咪唑. 中国科学B, 2008, 38: 288-293.

53.     Han Q. J., Wu H. L.,* Nie J. F., Xia A L., Zhu S. H., Yu R. Q. Direct determination of reserpine in urine using excitation-emission fluorescence combined with three-way chemometric calibration methodologies. Frontiers of Chemistry in China-Selected Publications from Chinese Universities, 2008, 3: 224-228.

54.     Wang X. M., Wu H. L.,* Nie J. F., Li Y. N., Yu Y. J., Yu R. Q. Rapid determination of thiabendazole in orange extract using excitation-emission matrix fluorescence and second-order calibration based on alternating trilinear decomposition/alternating normalization-weighted error algorithms. Science in China, Series B: Chemistry, 2008, 51: 729-735.

55.     Nie J. F., Wu H. L.*, Xia A. L., Zhu S. H., Bian Y. C., Li S. F., Yu R. Q., Determination of sulpiride in human urine using excitation-emission matrix fluorescence coupled with second-order calibration. Analytical Sciences, 2007, 23: 1377-1382.

 

 

发布日期:2020-06-15       浏览次数:

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